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Topical Reviews
Jonathon P. Fanning , Allan J. Wesley , Andrew A. Wong , John F. Fraser
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Stroke. 2014; 45: 3461-3471
Jonathon P. Fanning
From the School of Medicine (J.P.F., A.J.W., A.A.W., J.F.F.) and Critical Care Research Group (CCRG), The Prince Charles Hospital (J.P.F., J.F.F.), The University of Queensland, Brisbane, Queensland, Australia; Department of Medical Imaging (A.J.W.) and Adult Intensive Care Services (J.F.F.), The Prince Charles Hospital, Brisbane, Queensland, Australia; Department of Medical Imaging, Monash Medical Centre, Melbourne, Victoria, Australia (A.J.W.); and Department of Neurology, The Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia (A.A.W.).
Allan J. Wesley
From the School of Medicine (J.P.F., A.J.W., A.A.W., J.F.F.) and Critical Care Research Group (CCRG), The Prince Charles Hospital (J.P.F., J.F.F.), The University of Queensland, Brisbane, Queensland, Australia; Department of Medical Imaging (A.J.W.) and Adult Intensive Care Services (J.F.F.), The Prince Charles Hospital, Brisbane, Queensland, Australia; Department of Medical Imaging, Monash Medical Centre, Melbourne, Victoria, Australia (A.J.W.); and Department of Neurology, The Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia (A.A.W.).
Andrew A. Wong
From the School of Medicine (J.P.F., A.J.W., A.A.W., J.F.F.) and Critical Care Research Group (CCRG), The Prince Charles Hospital (J.P.F., J.F.F.), The University of Queensland, Brisbane, Queensland, Australia; Department of Medical Imaging (A.J.W.) and Adult Intensive Care Services (J.F.F.), The Prince Charles Hospital, Brisbane, Queensland, Australia; Department of Medical Imaging, Monash Medical Centre, Melbourne, Victoria, Australia (A.J.W.); and Department of Neurology, The Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia (A.A.W.).
John F. Fraser
From the School of Medicine (J.P.F., A.J.W., A.A.W., J.F.F.) and Critical Care Research Group (CCRG), The Prince Charles Hospital (J.P.F., J.F.F.), The University of Queensland, Brisbane, Queensland, Australia; Department of Medical Imaging (A.J.W.) and Adult Intensive Care Services (J.F.F.), The Prince Charles Hospital, Brisbane, Queensland, Australia; Department of Medical Imaging, Monash Medical Centre, Melbourne, Victoria, Australia (A.J.W.); and Department of Neurology, The Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia (A.A.W.).

Silent brain infarction (SBI) is an increasingly recognized, and yet still poorly understood, clinical disorder characterized by the often incidental finding of cerebral infarction on imaging in the absence of clinically apparent neurological deficit. Although first described ≈50 years ago by Fisher 1 through autopsy studies, it was not until the development of more sensitive imaging modalities that their characterization has been possible.

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